FB-IS-002In Silico2026-05-28
Dynamic Association of SS-31 with Cardiolipin and the PLSCR3 Interface in a Model Inner-Membrane Bilayer
Abstract
A membrane-embedded interaction study modeling the aromatic-cationic tetrapeptide SS-31 against cardiolipin and a PLSCR3 interface model. Association trajectories were sampled and characterized by electrostatic contact persistence and aromatic stacking occupancy. Reported as structural reference data; no physiological effect is asserted.
Methods
- 01Bilayer construction : cardiolipin-enriched inner-membrane model
- 02Association sampling : all-atom dynamics, multiple replicas
- 03Contact analysis : salt-bridge persistence, π-stacking occupancy
- 04Anonymized trajectory export : reference frames only
DISCLOSURE : This report presents anonymized in-silico and/or observational reference data. It does not establish a causal relationship between any catalogued material and any physiological outcome, and it is not a claim of safety, efficacy, or benefit.
Relevant Reference Materials
This report's structural and literature findings are studied against the following catalogued reference material.